Crohn's+Disease

A. Name of disease: Crohns Disease B. Root cause of disease: Genetics/Hereditary/Enviromental Factors C. Affected cell types/tissues/organs/systems: Gastrointestinal Tract. Usually in the end of the small bowel (the ileum) and the beginning of the colon, but can be anywhere along the GI tract from mouth to anus. D. Historical background: Named after Dr. Burrill B. Crohn, who first described the disease in 1932 along with colleagues Dr. Leon Ginzburg and Dr. Gordon D. Oppenheimer, Crohn’s disease belongs to a group of conditions known as Inflammatory Bowel Diseases (IBD).

E. Common symptoms: Persistent Diarrhea Rectal bleeding Urgent need to move bowels Abdominal cramps and pain Sensation of incomplete evacuation Constipation (can lead to bowel obstruction)

General symptoms that may also be associated with IBD: Fever Loss of appetite Weight Loss Fatigue Night sweats Loss of normal menstrual cycle F. Standard treatments: (University of Illinois at Chicago, 2012) G. Current research: Beltran, B., Iborra, M., Moret, I., Gimenez, J., Bastoda, G., Rausell, F.,. . . Nos, P. (2009). T1696 Permanent Impairment of Catalase Activity Due to a Minor Expression of Catalase Protein in Peripheral White Mononuclear Cells (PWMC)of Patients with Naïve and Treated Crohns Disease (CD). //Gastroenterology, 136//(5), 560. Retrieved from http://dx.doi.org/10.1016/S0016-5085(09)62576-2 Crohn's & Colitis Foundation of America. (2012). //What is Crohn's Disease//. Retrieved from Crohn's & Colitis Foundation of America: http://www.ccfa.org/what-are-crohns-and-colitis/what-is-crohns-disease/ Gilja, O. (2009). 0470: Ultrasound in Crohns Disease. //Ultrasound in Medicine & Biology, 35//(8), 64. Retrieved from http://dx.doi.org/10.1016/j.ultrasmedbio.2009.06.253 Sebastian, S., Ashton, K., Houston, Y., Diggory, T., & Dore, P. (2012). Anti-TNF Therapy induced immune neutropenia in Crohns disease- report of 2 cases and review of literature. //Journal of Crohn's and Colitis, 6//(6), 713-716. Retrieved from http://dx.doi.org/10.1016/j.crohns.2012.01.014 University of Illinois at Chicago. (2012). //Crohn's Disease Physician Flow Chart//. Retrieved from University of Illinois Medical Center at Chicago: http://www.uic.edu/com/dom/ibd/Crohns.html